Prostacyclin-Deficient Mice Develop Ischemic Renal Disorders, Including Nephrosclerosis and Renal Infarction
نویسندگان
چکیده
منابع مشابه
Prostacyclin-deficient mice develop ischemic renal disorders, including nephrosclerosis and renal infarction.
BACKGROUND Prostacyclin (PGI2) is a short-lived endogenous inhibitor of platelet aggregation and a potent vasodilator and regulator of the growth of vascular smooth muscle cells. To study the role of PGI2 in the vascular system in vivo, PGI2-deficient (PGID) mice were established by genetic disruption of the PGI2 synthase gene. METHODS AND RESULTS PGI2 synthase-null mice were generated by rep...
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ژورنال
عنوان ژورنال: Circulation
سال: 2002
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000034733.93020.bc